The Kofa Refuge and Wilderness is located between Yuma and Quartzsite, Arizona east of U.S. Highway 95. The southernmost of the six entrance roads is found about 40 miles north of Yuma and leads to the southern Castle Dome Mountains. Other popular entrances are located at King Valley, Palm Canyon, and Crystal Hill, which is the northernmost entrance 10 miles south of Quartzsite. An exit off U.S. Interstate 10 at the Vicksburg Road provides access to the northeast corner of the Refuge.
Old roads, remnants mostly from the mining era, connect all areas of the Refuge; therefore, explorers can negotiate the Refuge from north to south or east to west. Four-wheel drive vehicles are a must; some of the more remote sections of the Refuge will take 3 - 4 hours of driving to reach from the highway.
There are no visitor facilities on the Refuge. The nearest restaurants and motels are found in Yuma and Quartzsite. Gas stations are located in Yuma, Quartzsite and at Interstate 10 and the Vicksburg Road (Exit 45). The Refuge Office is located in Yuma at 9300 E. 28th Street.