The Powderhorn Wilderness is located about 230 miles southwest of Denver, about 30 miles south of Gunnison, and about 7 miles northeast of Lake City, Colorado. There are 5 trailheads. Entrances on the north end include the Powderhorn Lakes and the Ten Mile Springs Trailheads. The Devil's Creek Trailhead is on the west side of the area and the Powderhorn Park Trailhead is on the southeast side of the Wilderness. The Brush Creek Trailhead is on the south end of the Wilderness. Visitor Centers and BLM/FS Offices in both Gunnison and Lake City provide maps and directions to these trailheads.