Cape Romain Wilderness
The south boundary is located 14 miles northeast of Mount Pleasant, South Carolina. The north boundary is 5 miles east of McClellanville, South Carolina. The wilderness lies east of the Intracoastal Waterway. The Refuge is bordered by Capers Island to the south and Murphy Island to the north, both S.C. Department of Natural Resources protected lands. To the west of the Intracoastal Waterway lies the Francis Marion National Forest.